Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:596
Symbol:BCL2
Full Name:B-cell CLL/lymphoma 2
Alias:Bcl-2
Organism:Homo sapiens (Human)
Chromosome:18
Genetic Location:18q21.33|18q21.3
Physical Location:58941558-59137592 on NC_000018.8, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 12043 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:BCL2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000633.2NP_000624.2NC_000018.8 range: 58941558..59137592, complement
NM_000657.2NP_000648.2NC_000018.8 range: 58941558..59137592, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0031965nuclear membraneCellular ComponentIDA (1502141)
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005741mitochondrial outer membraneCellular ComponentTAS (1453000)
GO:0005741mitochondrial outer membraneCellular ComponentIDA (9027314)
GO:0005741mitochondrial outer membraneCellular ComponentEXP (10198631|11463392|12624108)
GO:0005739mitochondrionCellular ComponentIDA (9027314)
GO:0005737cytoplasmCellular ComponentIDA (11530860)
GO:0005634nucleusCellular ComponentIEA
GO:0042803protein homodimerization activityMolecular FunctionIDA (9111042)
GO:0046982protein heterodimerization activityMolecular FunctionIPI (9111042)
GO:0051434BH3 domain bindingMolecular FunctionIPI (9111042)
GO:0002020protease bindingMolecular FunctionIDA (10620603)
GO:0051402neuron apoptosisBiological ProcessTAS (16167175)
GO:0042493response to drugBiological ProcessIDA (8949945)
GO:0051881regulation of mitochondrial membrane potentialBiological ProcessISS (9843949)
GO:0051607defense response to virusBiological ProcessIDA (10620603)
GO:0042981regulation of apoptosisBiological ProcessIEA
GO:0043496regulation of protein homodimerization activityBiological ProcessIDA (9111042)
GO:0043497regulation of protein heterodimerization activityBiological ProcessIDA (9111042)
GO:0046902regulation of mitochondrial membrane permeabilityBiological ProcessISS (9843949)
GO:0042100B cell proliferationBiological ProcessIDA (1373874)
GO:0035094response to nicotineBiological ProcessIDA (12421819)
GO:0006916anti-apoptosisBiological ProcessIDA (9027314|10506221|10620603|11684014)
GO:0006959humoral immune responseBiological ProcessTAS (1908951)
GO:0007565female pregnancyBiological ProcessNAS (11530860)
GO:0008219cell deathBiological ProcessIDA (8949945)
GO:0008633activation of pro-apoptotic gene productsBiological ProcessEXP (15231831)
GO:0009314response to radiationBiological ProcessNAS (15799693)
GO:0009636response to toxinBiological ProcessIDA (16307838)
GO:0010039response to iron ionBiological ProcessIDA (11264898)
GO:0001836release of cytochrome c from mitochondriaBiological ProcessNAS (9027314)
GO:0032848negative regulation of cellular pH reductionBiological ProcessIDA (10506221)
GO:0034097response to cytokine stimulusBiological ProcessIDA (9184696)
GO:0051902negative regulation of mitochondrial depolarizationBiological ProcessTAS (9027314)
Other Database Cross Links
NCBI Entrez Gene:596
HGNC:990
Ensembl:ENSG00000171791
MIM:151430
HPRD:01045
HuGE Navigator:596
dbSNP:BCL2
GeneCard:BCL2
AceView:BCL2