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Gene Information
Gene ID:12064
Symbol:Bdnf
Full Name:brain derived neurotrophic factor
Organism:Mus musculus (Mouse)
Chromosome:2
Genetic Location:2 E3|2 62.0 cM
Physical Location:109514856-109567199 on NC_000068.6
Gene Type:protein-coding
Human Ortholog:GeneID: 627    Symbol (Name): BDNF (brain-derived neurotrophic factor)
Ortholog Status:The human GeneID 627 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Bdnf
Original ID2:X55573
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001048139.1NP_001041604.1NC_000068.6 range: 109514856..109567199
NM_001048141.1NP_001041606.1NC_000068.6 range: 109514856..109567199
NM_001048142.1NP_001041607.1NC_000068.6 range: 109514856..109567199
NM_007540.4NP_031566.4NC_000068.6 range: 109514856..109567199
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016023cytoplasmic membrane-bounded vesicleCellular ComponentIDA (14715936|15242649)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005788endoplasmic reticulum lumenCellular ComponentEXP (925010)
GO:0005515protein bindingMolecular FunctionIPI (11684666)
GO:0008083growth factor activityMolecular FunctionIEA
GO:0042490mechanoreceptor differentiationBiological ProcessIGI (15376326)
GO:0021675nerve developmentBiological ProcessIMP (7605630)
GO:0001657ureteric bud developmentBiological ProcessIDA (16018995)
GO:0042493response to drugBiological ProcessIMP (15249684)
GO:0042596fear responseBiological ProcessIMP (15249684)
GO:0043523regulation of neuron apoptosisBiological ProcessIDA (16516892)
GO:0043524negative regulation of neuron apoptosisBiological ProcessIMP (8861722)
GO:0045666positive regulation of neuron differentiationBiological ProcessIDA (12798291)
GO:0046668regulation of retinal cell programmed cell deathBiological ProcessIDA (11747369)
GO:0048167regulation of synaptic plasticityBiological ProcessIDA (16819522|17442827)
GO:0019222regulation of metabolic processBiological ProcessIMP (12106019)
GO:0016358dendrite developmentBiological ProcessIMP (12890780)
GO:0006916anti-apoptosisBiological ProcessIDA (12904469)
GO:0007406negative regulation of neuroblast proliferationBiological ProcessIDA (12798291)
GO:0007411axon guidanceBiological ProcessIMP (15014133)
GO:0007412axon target recognitionBiological ProcessIMP (15464571)
GO:0007610behaviorBiological ProcessIMP (15249684)
GO:0007611learning and/or memoryBiological ProcessIMP (15249684)
GO:0007631feeding behaviorBiological ProcessIMP (12796784)
GO:0008038neuron recognitionBiological ProcessIMP (15844198)
GO:0014047glutamate secretionBiological ProcessIPI (16819522)
GO:0048839inner ear developmentBiological ProcessIMP (7605630)
Other Database Cross Links
NCBI Entrez Gene:12064
MGI:
Ensembl:ENSMUSG00000048482
dbSNP:Bdnf
AceView:Bdnf