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Gene Information
Gene ID:12286
Symbol:Cacna1a
Full Name:calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Alias:APCA|Caca1a|Cacnl1a4|Cav2.1|Ccha1a|EA2|FHM|HPCA|MHP|MHP1|SCA6|alpha1A|la|leaner|nmf352|rkr|rocker|tg|tottering
Organism:Mus musculus (Mouse)
Chromosome:8
Genetic Location:8 C3|8 38.5 cM
Physical Location:86939262-87164147 on NC_000074.5
Gene Type:protein-coding
Human Ortholog:GeneID: 773    Symbol (Name): CACNA1A (calcium channel, voltage-dependent, P/Q type, alpha 1A subunit)
Ortholog Status:The human GeneID 773 is also in human dataset(s).
Gene in Ethanol Study Datasets
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Caws3/Alcw6Chronic Alcohol Withdrawal8 16-43 (cM)3.50.0003SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007578.3NP_031604.3NC_000074.5 range: 86939262..87164147
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043025cell somaCellular ComponentIDA (15451373)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentRCA (16141072)
GO:0005891voltage-gated calcium channel complexCellular ComponentIDA (10328888)
GO:0030425dendriteCellular ComponentIDA (15451373)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0008331high voltage-gated calcium channel activityMolecular FunctionIMP (9742139|10908603|11344116|11718712|12040045|12065603|12401561|12624181|15548652)
GO:0008331high voltage-gated calcium channel activityMolecular FunctionIGI (11756409)
GO:0005515protein bindingMolecular FunctionIPI (1370480|10328888)
GO:0005262calcium channel activityMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionRCA (16141072)
GO:0005245voltage-gated calcium channel activityMolecular FunctionIMP (9614225|9857013|10611370|12151514|12827191)
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005245voltage-gated calcium channel activityMolecular FunctionIDA (8632762)
GO:0043113receptor clusteringBiological ProcessIMP (12624181)
GO:0042445hormone metabolic processBiological ProcessIMP (8229069|8957685)
GO:0042403thyroid hormone metabolic processBiological ProcessIMP
GO:0042391regulation of membrane potentialBiological ProcessIMP (1355109|1572065|9614225|9857013|10670432|12151514|12401561)
GO:0042133neurotransmitter metabolic processBiological ProcessIMP (1686215|6167317|8100981)
GO:0035249synaptic transmission, glutamatergicBiological ProcessIMP (10322048|14973254)
GO:0030644cellular chloride ion homeostasisBiological ProcessIMP (8565963|10899223)
GO:0032353negative regulation of hormone biosynthetic processBiological ProcessIMP (11182254)
GO:0043524negative regulation of neuron apoptosisBiological ProcessIMP (4941467|8929530)
GO:0060024rhythmic synaptic transmissionBiological ProcessIMP (16474392)
GO:0051932synaptic transmission, GABAergicBiological ProcessIMP (10322048)
GO:0051899membrane depolarizationBiological ProcessIMP (8158221|10908603|11718712)
GO:0050905neuromuscular processBiological ProcessIMP (11344116)
GO:0050905neuromuscular processBiological ProcessIGI (10630211)
GO:0050885neuromuscular process controlling balanceBiological ProcessIMP (4799944)
GO:0050883musculoskeletal movement, spinal reflex actionBiological ProcessIMP (11718712)
GO:0050877neurological system processBiological ProcessIMP (1486501|6462226)
GO:0050770regulation of axonogenesisBiological ProcessIMP (572084)
GO:0048813dendrite morphogenesisBiological ProcessIMP (10336181|11160387|14973254)
GO:0048791calcium ion-dependent exocytosis of neurotransmitterBiological ProcessIMP (10670432)
GO:0048266behavioral response to painBiological ProcessIMP (16890369)
GO:0048265response to painBiological ProcessIMP (11718712)
GO:0021953central nervous system neuron differentiationBiological ProcessIMP (6945603)
GO:0021750vestibular nucleus developmentBiological ProcessIMP (8719615)
GO:0007274neuromuscular synaptic transmissionBiological ProcessIMP (10686170)
GO:0007270nerve-nerve synaptic transmissionBiological ProcessIMP (16540584)
GO:0007268synaptic transmissionBiological ProcessIMP (10611370|12040045|15548652)
GO:0007214gamma-aminobutyric acid signaling pathwayBiological ProcessIMP (8565963)
GO:0007204elevation of cytosolic calcium ion concentrationBiological ProcessRCA (16141072)
GO:0007204elevation of cytosolic calcium ion concentrationBiological ProcessIDA (8632762)
GO:0006816calcium ion transportBiological ProcessIMP (9614225|9857013|12827191)
GO:0006811ion transportBiological ProcessIEA
GO:0006810transportBiological ProcessIEA
GO:0006006glucose metabolic processBiological ProcessIMP (8957685)
GO:0007416synaptogenesisBiological ProcessIMP (10336181|14973254)
GO:0007628adult walking behaviorBiological ProcessIGI (8719807|9882694)
GO:0007628adult walking behaviorBiological ProcessIMP (4799944|4941467|8719807|10611370|11160387|11344116|12401561|13950100|16890369)
GO:0021702cerebellar Purkinje cell differentiationBiological ProcessIMP (1306163|7834360|10630211)
GO:0021680cerebellar Purkinje cell layer developmentBiological ProcessIMP (1306163)
GO:0021679cerebellar molecular layer developmentBiological ProcessIMP (7697385)
GO:0021590cerebellum maturationBiological ProcessIMP (11344116)
GO:0019226transmission of nerve impulseBiological ProcessIMP (1355109|1469420|1572065)
GO:0017158regulation of calcium ion-dependent exocytosisBiological ProcessIDA (8632762)
GO:0017156calcium ion-dependent exocytosisBiological ProcessIMP (12065603)
GO:0016049cell growthBiological ProcessIMP (1306163)
GO:0014056regulation of acetylcholine secretionBiological ProcessIMP (10686170|12624181)
GO:0014051gamma-aminobutyric acid secretionBiological ProcessIMP (10670432)
GO:0000096sulfur amino acid metabolic processBiological ProcessIMP (1485534)
Other Database Cross Links
NCBI Entrez Gene:12286
MGI:
Ensembl:ENSMUSG00000034656
dbSNP:Cacna1a
AceView:Cacna1a