ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Capzb

Full Name:

capping protein (actin filament) muscle Z-line, beta

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 D3|4 66.8 cM

Physical Location:

138748845-138847726 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 832 Symbol (Name): CAPZB (capping protein (actin filament) muscle Z-line, beta)

Ortholog Status:

The human GeneID 832 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Capzb
Original ID2:		AV107153

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Information

Original ID1:

Capzb

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap3q	Alcohol Preference Drinking	4	75	65-ter (cM)	4.6		Significant	PARC

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030018	Z disc	Cellular Component	ISS (7929588)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0008290	F-actin capping protein complex	Cellular Component	IEA
GO:0014704	intercalated disc	Cellular Component	ISS (7929588)
GO:0030027	lamellipodium	Cellular Component	IDA (15294161)
GO:0003779	actin binding	Molecular Function	IEA
GO:0030030	cell projection organization and biogenesis	Biological Process	IMP (15294161)
GO:0030032	lamellipodium biogenesis	Biological Process	IMP (15294161)
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IEA
GO:0051016	barbed-end actin filament capping	Biological Process	IEA