ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Casp9

Full Name:

caspase 9

Alias:

AI115399|AW493809|Caspase-9|ICE-LAP6|Mch6

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 E1

Physical Location:

141349526-141371889 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 842 Symbol (Name): CASP9 (caspase 9, apoptosis-related cysteine peptidase)

Ortholog Status:

The human GeneID 842 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AB019600
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_015733.4	NP_056548.2	NC_000070.5 range: 141349526..141371889

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	RCA (12466851)
GO:0005625	soluble fraction	Cellular Component	IDA (15271982)
GO:0005634	nucleus	Cellular Component	IDA (15271982)
GO:0005829	cytosol	Cellular Component	IDA (15271982)
GO:0005515	protein binding	Molecular Function	IPI (14561754)
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0030693	caspase activity	Molecular Function	IDA (14561754\|16183742)
GO:0030693	caspase activity	Molecular Function	RCA (12819136)
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0042981	regulation of apoptosis	Biological Process	RCA (12466851)
GO:0009411	response to UV	Biological Process	IMP (11092819)
GO:0006974	response to DNA damage stimulus	Biological Process	IMP (11092819)
GO:0006917	induction of apoptosis	Biological Process	RCA (12819136)
GO:0006915	apoptosis	Biological Process	RCA (12466851)
GO:0006508	proteolysis	Biological Process	RCA (12466851\|12819136)
GO:0043525	positive regulation of neuron apoptosis	Biological Process	IMP (11092819)