ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

12387

Symbol:

Ctnnb1

Full Name:

catenin (cadherin associated protein), beta 1

Alias:

Catnb|Mesc

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 F4|9 72.0 cM

Physical Location:

120842592-120869624 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1499 Symbol (Name): CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa)

Ortholog Status:

The human GeneID 1499 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Catnb
Original ID2:		M90364

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007614.2	NP_031640.1	NC_000075.5 range: 120842592..120869624

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IDA (16418220)
GO:0016323	basolateral plasma membrane	Cellular Component	IDA (9950951\|12885771\|14625387\|15226261)
GO:0005916	fascia adherens	Cellular Component	IDA (16481394)
GO:0005913	cell-cell adherens junction	Cellular Component	IDA (11731229\|14657280\|15148305\|15292239\|15645444\|16199027)
GO:0005912	adherens junction	Cellular Component	IDA (12203715\|12695331)
GO:0005624	membrane fraction	Cellular Component	IDA (12432063\|12611902\|14657280)
GO:0005634	nucleus	Cellular Component	IDA (11731231\|11731265\|11872843\|12874278\|12885771\|12923052\|15371327\|15778706\|15866163\|15866165\|16439479\|1)
GO:0005667	transcription factor complex	Cellular Component	IDA (12464179\|12861022\|16678101)
GO:0005737	cytoplasm	Cellular Component	IDA (11731231\|11731265\|12235125\|12923052\|15525667)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005911	intercellular junction	Cellular Component	IDA (9950951\|12181493\|14597196)
GO:0016328	lateral plasma membrane	Cellular Component	ISO
GO:0045177	apical part of cell	Cellular Component	IDA (14758363\|15037549\|16339037)
GO:0031528	microvillus membrane	Cellular Component	IDA (16439479)
GO:0016020	membrane	Cellular Component	IDA (8821035\|11731231\|15987773)
GO:0043296	apical junction complex	Cellular Component	IDA (16249236\|17666436)
GO:0016328	lateral plasma membrane	Cellular Component	IDA (15645444)
GO:0030027	lamellipodium	Cellular Component	IDA (14657280)
GO:0030018	Z disc	Cellular Component	IDA (8821035)
GO:0016563	transcription activator activity	Molecular Function	IDA (10631168\|16936075)
GO:0045294	alpha-catenin binding	Molecular Function	IPI (12432063)
GO:0008134	transcription factor binding	Molecular Function	IPI (16678101)
GO:0045296	cadherin binding	Molecular Function	IPI (15057752)
GO:0003682	chromatin binding	Molecular Function	IDA (15024079\|15778706\|15907834\|16678101\|16818445)
GO:0003677	DNA binding	Molecular Function	IDA (12235125)
GO:0003690	double-stranded DNA binding	Molecular Function	IDA (16678101)
GO:0003700	transcription factor activity	Molecular Function	IDA (12235125)
GO:0003713	transcription coactivator activity	Molecular Function	IDA (12464179)
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (9488439\|11104755\|12432063\|12695331\|12861022\|12874278\|14647292\|14960280\|15327768\|15834408)
GO:0005488	binding	Molecular Function	IEA
GO:0042733	embryonic digit morphogenesis	Biological Process	IMP (12923052)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IMP (15024079)
GO:0048469	cell maturation	Biological Process	IMP (15576404)
GO:0042475	odontogenesis of dentine-containing teeth	Biological Process	IMP (15866165)
GO:0042127	regulation of cell proliferation	Biological Process	IDA (12235125)
GO:0048489	synaptic vesicle transport	Biological Process	IMP (14622577)
GO:0060070	Wnt receptor signaling pathway through beta-catenin	Biological Process	IGI (16678101\|16818445)
GO:0048593	camera-type eye morphogenesis	Biological Process	IMP (16102745)
GO:0050808	synapse organization and biogenesis	Biological Process	IMP (14622577)
GO:0035117	embryonic arm morphogenesis	Biological Process	IDA (15371327)
GO:0035116	embryonic hindlimb morphogenesis	Biological Process	IMP (12923052)
GO:0032331	negative regulation of chondrocyte differentiation	Biological Process	IGI (16818445)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (15907834)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15729346\|15778706\|16678101)
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA (10631168\|16936075)
GO:0045671	negative regulation of osteoclast differentiation	Biological Process	IMP (15866165)
GO:0045669	positive regulation of osteoblast differentiation	Biological Process	IMP (15866163)
GO:0045667	regulation of osteoblast differentiation	Biological Process	IMP (15576404)
GO:0045596	negative regulation of cell differentiation	Biological Process	IMP (15866163\|16102745)
GO:0045595	regulation of cell differentiation	Biological Process	IDA (12717450)
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IMP (15866163)
GO:0045453	bone resorption	Biological Process	IMP (15866165)
GO:0045453	bone resorption	Biological Process	IGI (15866165)
GO:0045449	regulation of transcription	Biological Process	IDA (12464179)
GO:0045941	positive regulation of transcription	Biological Process	IMP (15866163)
GO:0031016	pancreas development	Biological Process	IMP (16192304)
GO:0030900	forebrain development	Biological Process	IMP (15708565)
GO:0030858	positive regulation of epithelial cell differentiation	Biological Process	IMP (16040629)
GO:0007160	cell-matrix adhesion	Biological Process	IMP (15131783)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IMP (15131783)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (12235125)
GO:0006350	transcription	Biological Process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (16040629)
GO:0001711	endodermal cell fate commitment	Biological Process	IMP (12194849)
GO:0001709	cell fate determination	Biological Process	IMP (15708565)
GO:0001708	cell fate specification	Biological Process	IMP (15866163)
GO:0001706	endoderm formation	Biological Process	IMP (12194849)
GO:0001702	gastrulation with mouth forming second	Biological Process	IMP (8582267)
GO:0001569	patterning of blood vessels	Biological Process	IMP (12975353)
GO:0001501	skeletal development	Biological Process	IMP (15866163)
GO:0007268	synaptic transmission	Biological Process	IMP (14622577)
GO:0007507	heart development	Biological Process	IMP (12464179)
GO:0008283	cell proliferation	Biological Process	IMP (15131783)
GO:0030324	lung development	Biological Process	IMP (12885771)
GO:0030316	osteoclast differentiation	Biological Process	IMP (15866165)
GO:0030154	cell differentiation	Biological Process	IMP (15131783\|16192304)
GO:0030097	hemopoiesis	Biological Process	IDA (12717450)
GO:0016337	cell-cell adhesion	Biological Process	IMP (16102745)
GO:0016331	morphogenesis of embryonic epithelium	Biological Process	IMP (16102745)
GO:0007398	ectoderm development	Biological Process	IMP (8582267)
GO:0016055	Wnt receptor signaling pathway	Biological Process	IDA (12235125\|12464179\|12717450)
GO:0009987	cellular process	Biological Process	IDA (12717450)
GO:0009954	proximal/distal pattern formation	Biological Process	IMP (12885771)
GO:0009953	dorsal/ventral pattern formation	Biological Process	IMP (15708565)
GO:0009950	dorsal/ventral axis specification	Biological Process	IMP (12923052)
GO:0009948	anterior/posterior axis specification	Biological Process	IMP (10662781)
GO:0000904	cellular morphogenesis during differentiation	Biological Process	IMP (16102745)