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Gene Information
Gene ID:12424
Full Name:cholecystokinin
Organism:Mus musculus (Mouse)
Genetic Location:9 F4|9 71.0 cM
Physical Location:121398942-121404779 on NC_000075.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 885    Symbol (Name): CCK (cholecystokinin)
Ortholog Status:The human GeneID 885 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cck
Original ID2:X59520
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Etact2Alcohol Stimulated Activity96151-71 (cM)3.64.30E-05SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031161.2NP_112438.1NC_000075.5 range: 121398942..121404779, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0030424axonCellular ComponentIDA (15152034)
GO:0005179hormone activityMolecular FunctionIEA
GO:0005184neuropeptide hormone activityMolecular FunctionIDA (15374756)
GO:0001764neuron migrationBiological ProcessIDA (15152034)
GO:0007409axonogenesisBiological ProcessIDA (15152034)
GO:0042755eating behaviorBiological ProcessIDA (15374756)
Other Database Cross Links
NCBI Entrez Gene:12424