| Gene Information |
| Gene ID: | | 12424 |
| Symbol: | | Cck |
| Full Name: | | cholecystokinin |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 9 |
| Genetic Location: | | 9 F4|9 71.0 cM |
| Physical Location: | | 121398942-121404779 on NC_000075.5, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 885 Symbol (Name): CCK (cholecystokinin) |
| Ortholog Status: | | The human GeneID 885 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Cck | | Original ID2: | | X59520 |
| | Dataset Information | | Name: | | 15745951 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens, prefrontal cortex, and ventral tegmental area | | Phenotype: | | Acute ethanol response | | Publication: | | Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed | | Summary: | | The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area. |
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| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Etact2 | Alcohol Stimulated Activity | 9 | 61 | 51-71 (cM) | 3.6 | 4.30E-05 | Significant | PARC |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | IEA | |
| GO:0005615 | extracellular space | Cellular Component | RCA (12466851) | |
| GO:0030424 | axon | Cellular Component | IDA (15152034) | |
| GO:0005179 | hormone activity | Molecular Function | IEA | |
| GO:0005184 | neuropeptide hormone activity | Molecular Function | IDA (15374756) | |
| GO:0001764 | neuron migration | Biological Process | IDA (15152034) | |
| GO:0007409 | axonogenesis | Biological Process | IDA (15152034) | |
| GO:0042755 | eating behavior | Biological Process | IDA (15374756) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 12424 |
| MGI: | |
| Ensembl: | | ENSMUSG00000032532 |
| dbSNP: | | Cck |
| AceView: | | Cck |
