ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ccr6

Full Name:

chemokine (C-C motif) receptor 6

Alias:

Cmkbr6

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 A1

Physical Location:

8435390-8449991 on NC_000083.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1235 Symbol (Name): CCR6 (chemokine (C-C motif) receptor 6)

Ortholog Status:

The human GeneID 1235 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ccr6
Original ID2:		AJ222714

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009835.3	NP_033965.1	NC_000083.5 range: 8435390..8449991

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (9862452)
GO:0004945	angiotensin type II receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0016493	C-C chemokine receptor activity	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA