ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cd28

Full Name:

CD28 antigen

Organism:

Mus musculus (Mouse)

Chromosome:

1

Genetic Location:

1 C1-C3|1 30.1 cM

Physical Location:

60803309-60830202 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 940 Symbol (Name): CD28 (CD28 molecule)

Ortholog Status:

The human GeneID 940 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws1/Alcw5	Chronic Alcohol Withdrawal	1		28-47 (cM)	6.5	3.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007642.4	NP_031668.3	NC_000067.5 range: 60803309..60830202

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0009897	external side of plasma membrane	Cellular Component	ISO
GO:0005886	plasma membrane	Cellular Component	ISO
GO:0009897	external side of plasma membrane	Cellular Component	IDA (7790813\|8125140)
GO:0009897	external side of plasma membrane	Cellular Component	IMP (7688139)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0045060	negative thymic T cell selection	Biological Process	IMP (10429671)
GO:0045086	positive regulation of interleukin-2 biosynthetic process	Biological Process	IMP (7688139)
GO:0002863	positive regulation of inflammatory response to antigenic stimulus	Biological Process	IMP (10791997)
GO:0046641	positive regulation of alpha-beta T cell proliferation	Biological Process	IDA (8125140\|9368605)
GO:0046641	positive regulation of alpha-beta T cell proliferation	Biological Process	IMP (9368605)
GO:0042102	positive regulation of T cell proliferation	Biological Process	IMP (7688139\|10791997)
GO:0042102	positive regulation of T cell proliferation	Biological Process	IDA (12867038\|12925852\|15240667)
GO:0031295	T cell costimulation	Biological Process	IMP (7688139\|9368605)
GO:0031295	T cell costimulation	Biological Process	IDA (8125140\|9368605\|10429671\|12925852\|15240667)
GO:0008624	induction of apoptosis by extracellular signals	Biological Process	IDA (10429671)
GO:0006955	immune response	Biological Process	IEA
GO:0048304	positive regulation of isotype switching to IgG isotypes	Biological Process	IMP (7688139)

Other Database Cross Links

NCBI Entrez Gene:

MGI:

Ensembl:

ENSMUSG00000026012

dbSNP:

AceView: