ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

940

Symbol:

CD28

Full Name:

CD28 molecule

Alias:

MGC138290|Tp44

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33

Physical Location:

204279442-204310800 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12487 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CD28

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006139.2	NP_006130.1	NC_000002.10 range: 204279442..204310800

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (11285224)
GO:0016020	membrane	Cellular Component	IEA
GO:0009897	external side of plasma membrane	Cellular Component	IDA (11390434)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (9784967)
GO:0005886	plasma membrane	Cellular Component	EXP (11285224)
GO:0005886	plasma membrane	Cellular Component	IDA (11390434)
GO:0042802	identical protein binding	Molecular Function	NAS (3159820)
GO:0015026	coreceptor activity	Molecular Function	TAS (9784967)
GO:0045768	positive regulation of anti-apoptosis	Biological Process	TAS (8717514)
GO:0045840	positive regulation of mitosis	Biological Process	IDA (3159820)
GO:0045727	positive regulation of translation	Biological Process	NAS (12028592)
GO:0045086	positive regulation of interleukin-2 biosynthetic process	Biological Process	ISS
GO:0045086	positive regulation of interleukin-2 biosynthetic process	Biological Process	IDA (3875683)
GO:0045070	positive regulation of viral genome replication	Biological Process	NAS (7492435)
GO:0045840	positive regulation of mitosis	Biological Process	ISS
GO:0042102	positive regulation of T cell proliferation	Biological Process	TAS (9784967)
GO:0042102	positive regulation of T cell proliferation	Biological Process	ISS
GO:0042102	positive regulation of T cell proliferation	Biological Process	IDA (3159820)
GO:0042089	cytokine biosynthetic process	Biological Process	TAS (8717514)
GO:0007166	cell surface receptor linked signal transduction	Biological Process	TAS (9784967)
GO:0006959	humoral immune response	Biological Process	TAS (8717514)
GO:0006955	immune response	Biological Process	IEA
GO:0050690	regulation of defense response to virus by virus	Biological Process	EXP (11285224)