ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cdc42

Full Name:

cell division cycle 42 homolog (S. cerevisiae)

Alias:

AI747189|AU018915

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 D3|4 66.75 cM

Physical Location:

136875617-136892043 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 998 Symbol (Name): CDC42 (cell division cycle 42 (GTP binding protein, 25kDa))

Ortholog Status:

The human GeneID 998 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cdc42
Fold Change:		1.31
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap3q	Alcohol Preference Drinking	4	75	65-ter (cM)	4.6		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009861.2	NP_033991.1	NC_000070.5 range: 136875617..136892043, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0030175	filopodium	Cellular Component	RCA (12466851)
GO:0042995	cell projection	Cellular Component	IDA (15728722)
GO:0030742	GTP-dependent protein binding	Molecular Function	IPI (10954424)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10490598\|12773384\|15710388\|15996550\|16052498)
GO:0003924	GTPase activity	Molecular Function	TAS (10490598)
GO:0003924	GTPase activity	Molecular Function	RCA (12466851)
GO:0003924	GTPase activity	Molecular Function	ISS (12637522)
GO:0003924	GTPase activity	Molecular Function	IDA (10699171\|15249579)
GO:0046847	filopodium formation	Biological Process	IDA (10699171)
GO:0043552	positive regulation of phosphoinositide 3-kinase activity	Biological Process	IMP (15728722)
GO:0016337	cell-cell adhesion	Biological Process	TAS (10954424)
GO:0016197	endosome transport	Biological Process	TAS (10954424)
GO:0007266	Rho protein signal transduction	Biological Process	TAS (10490598)
GO:0007264	small GTPase mediated signal transduction	Biological Process	RCA (12466851)
GO:0007163	establishment and/or maintenance of cell polarity	Biological Process	TAS (10954424)
GO:0007097	nuclear migration	Biological Process	IMP (15882626)
GO:0007015	actin filament organization	Biological Process	RCA (12466851)
GO:0051301	cell division	Biological Process	IEA