Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:1267
Full Name:2',3'-cyclic nucleotide 3' phosphodiesterase
Organism:Homo sapiens (Human)
Genetic Location:17q21
Physical Location:37372284-37383279 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.273621
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original ID1:CNP
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_033133.4NP_149124.3NC_000017.9 range: 37372284..37383279
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0042470melanosomeCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIDA (12379507)
GO:0005622intracellularCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIDA (12379507)
GO:0016020membraneCellular ComponentIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:00041132',3'-cyclic-nucleotide 3'-phosphodiesterase activityMolecular FunctionTAS (8392017)
GO:0016070RNA metabolic processBiological ProcessIEA
GO:0007268synaptic transmissionBiological ProcessTAS (1322358)
GO:0009214cyclic nucleotide catabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:1267
HuGE Navigator:1267