| Gene Information |
| Gene ID: | | 127 |
| Symbol: | | ADH4 |
| Full Name: | | alcohol dehydrogenase 4 (class II), pi polypeptide |
| Alias: | | ADH-2 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 4 |
| Genetic Location: | | 4q21-q24|4q22 |
| Physical Location: | | 100263854-100284471 on NC_000004.10, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | 18477577 | | Method: | | Addiction array gene list | | Publication: | | Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed | | Summary: | | To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior. |
| | Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
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| Gene Information | | Original ID | No. of Publications | Phenotype | |
| ADH4 | 1 | Alcohol-Induced Disorders | | ADH4 | 1 | Alcohol-Induced Disorders Nervous System | | ADH4 | 4 | Alcoholism | | ADH4 | 3 | Alcohol-Related Disorders |
| | HuGE Navigator Dataset | | Name: | | HuGE Navigator | | Method: | | Literature data mining | | Publication: | | Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008]. | | Summary: | | HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia. |
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| Linkage Dataset | | Marker | LOD | P value | Location (bp) | |
| D4S423 | 2.61 | 0.0003 | 92691777 | | D4S427 | 3.53 | 0.00003 | 121646580 | | Region: | | 92691777-121646580 | | Phenotype: | | ADSX (number of DSM-IV AD symptoms) | | Name: | | 16534506 | | Method: | | Linkage | | Publication: | | Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed | | Summary: | | We conducted a genome scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). A 4 cM genome scan was conducted using 474 families of which most (96%) were comprised by affected sib pairs. Nonparametric and quantitative linkage analyses were conducted using DSM-IV alcohol dependence (AD) and number of DSM-IV AD symptoms (ADSX). Quantitative results indicate strong linkage for number of AD criteria to a broad region of chromosome 4, ranging from 4q22 to 4q32 (peak multipoint LOD=4.59, P=2.1 x 10(-6), at D4S1611). We got the gene list in the region between two markers D4S423 and D4S427 as markers between (included) these two markers have LOD scores >2 with P value <0.0003. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005737 | cytoplasm | Cellular Component | IEA | |
| GO:0004022 | alcohol dehydrogenase activity | Molecular Function | TAS (3036213) | |
| GO:0016491 | oxidoreductase activity | Molecular Function | IEA | |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | |
| GO:0046872 | metal ion binding | Molecular Function | IEA | |
| GO:0005488 | binding | Molecular Function | IEA | |
| GO:0004174 | electron-transferring-flavoprotein dehydrogenase activity | Molecular Function | TAS (3466164) | |
| GO:0006066 | alcohol metabolic process | Biological Process | TAS (3466164) | |
| GO:0006081 | aldehyde metabolic process | Biological Process | TAS (3466164) | |
| GO:0008152 | metabolic process | Biological Process | IEA | |
| GO:0006069 | ethanol oxidation | Biological Process | NR | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 127 |
| HGNC: | | 252 |
| Ensembl: | | ENSG00000198099 |
| MIM: | | 103740 |
| HPRD: | | 00068 |
| HuGE Navigator: | | 127 |
| dbSNP: | | ADH4 |
| GeneCard: | | ADH4 |
| AceView: | | ADH4 |
