ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

12704

Symbol:

Cit

Full Name:

citron

Alias:

C030025P15Rik|CRIK|CRIK-SK|Cit-k

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 F

Physical Location:

116295664-116456351 on NC_000071.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 11113 Symbol (Name): CIT (citron (rho-interacting, serine/threonine kinase 21))

Ortholog Status:

The human GeneID 11113 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF086824
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007708.3	NP_031734.3	NC_000071.5 range: 116295664..116456351

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (12781320)
GO:0015629	actin cytoskeleton	Cellular Component	IDA (9792683)
GO:0001726	ruffle	Cellular Component	IDA (12781320)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0019992	diacylglycerol binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (8543060)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (9792683)
GO:0005083	small GTPase regulator activity	Molecular Function	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0016358	dendrite development	Biological Process	IMP (12781320)
GO:0050774	negative regulation of dendrite morphogenesis	Biological Process	IDA (12781320)
GO:0048699	generation of neurons	Biological Process	IDA (11086988)
GO:0000070	mitotic sister chromatid segregation	Biological Process	IMP (12764032)
GO:0007399	nervous system development	Biological Process	IEA
GO:0000910	cytokinesis	Biological Process	IMP (11086988\|12432070)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0007067	mitosis	Biological Process	IEA
GO:0007091	mitotic metaphase/anaphase transition	Biological Process	IMP (12764032)
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007283	spermatogenesis	Biological Process	IMP (12432070)
GO:0051301	cell division	Biological Process	IEA