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Gene Information
Gene ID:12709
Symbol:Ckb
Full Name:creatine kinase, brain
Alias:B-CK|Ck-3
Organism:Mus musculus (Mouse)
Chromosome:12
Genetic Location:12 F1|12 55.0 cM
Physical Location:112907571-112910478 on NC_000078.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1152    Symbol (Name): CKB (creatine kinase, brain)
Ortholog Status:The human GeneID 1152 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M74149
Fold Change:2.5, 1.8
Note:ISS preferentially expressed gene. Two ratios of ISS/ILS are from cDNA array and RT-PCR.
Dataset Information
Name:11410715
Method:Microarray
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_021273.3NP_067248.1NC_000078.5 range: 112907571..112910478, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIDA (14651853)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0003824catalytic activityMolecular FunctionIEA
GO:0004111creatine kinase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0016772transferase activity, transferring phosphorus-containing groupsMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:12709
MGI:
Ensembl:ENSMUSG00000001270
dbSNP:Ckb
AceView:Ckb