ERGR - Ethanol-Related Gene Resource

Dataset Description

Dataset Name: 11410715

Species: Mouse

No. of Genes: 36

Tissue: Whole brain

Phenotype: Ethanol sensitivity

Publication: Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed

Dataset Summary: Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.

Gene list of this dataset (36 genes)

GeneID Symbol Name Genetic location Original ID1 Original ID2
16763 Lad1 ladinin 1 E4 U58011
18016 Nf2 neurofibromatosis 2 11 A1|11 0.25 cM L27090
AA120153
16453 Jak3 Janus kinase 3 8 B3.3|8 33.0 cM Q62137
20190 Ryr1 ryanodine receptor 1, skeletal muscle 7 A2-B3|7 10.0 cM U23754
12337 Capn5 calpain 5 7 E2 U85020
5157 D37965
52715 Ccdc43 coiled-coil domain containing 43 11 E1|11 60.0 cM W97942
13043 Cttn cortactin 7 F5 U03184
77106 Tmem181 transmembrane protein 181 17 A1 AA423204
AA432818
67392 4833420G17Rik RIKEN cDNA 4833420G17 gene 13 D2.3 W84055
381280 6430706D22Rik RIKEN cDNA 6430706D22 gene 1 D AA048171
71472 Usp19 ubiquitin specific peptidase 19 9 F2 AA254871
69908 Rab3b RAB3B, member RAS oncogene family 4 C7 AA030574
18115 Nnt nicotinamide nucleotide transhydrogenase 13 D2|13 64.0 cM AF037327
218232 Ptpdc1 protein tyrosine phosphatase domain containing 1 13 A5 AA388221
6183 AF058761
Z93024
67760 Slc38a2 solute carrier family 38, member 2 15 F1 AA245554
76000 5033430I15Rik RIKEN cDNA 5033430I15 gene 13 A5 AA221680
AC005324
54371 Chst2 carbohydrate sulfotransferase 2 - AB011451
27999 D6Wsu176e DNA segment, Chr 6, Wayne State University 176, expressed 6 A3.1|6 2.0 cM AA509602
319839 A530020G20Rik RIKEN cDNA A530020G20 gene 3 G1 AA543468
60347 X99330
23831 Car14 carbonic anhydrase 14 3 F2.1 AB005450
81761 D87515
3782 AF031815
73074 2900086B20Rik RIKEN cDNA 2900086B20 gene - AA060336
12709 Ckb creatine kinase, brain 12 F1|12 55.0 cM M74149
234407 Glt25d1 glycosyltransferase 25 domain containing 1 8 B3.3 W36470
18597 Pdha1 pyruvate dehydrogenase E1 alpha 1 X F3-F4|X 66.5 cM M76727
22709 Zfp51 zinc finger protein 51 17 A3.2|17 9.9 cM M74235
19063 Ppt1 palmitoyl-protein thioesterase 1 4 D1-D3|4 59.1 cM AF071025
15018 H2-Q7 histocompatibility 2, Q region locus 7 17 B1|17 19.19 cM X05389
319944 Taf2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor 15 D1 AA028778
76987 Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 18 E3 AA268225
15018 H2-Q7 histocompatibility 2, Q region locus 7 17 B1|17 19.19 cM X03210
170942 Erdr1 erythroid differentiation regulator 1 - AJ007909

GeneID	Symbol	Name	Genetic location	Original ID1	Original ID2
16763	Lad1	ladinin	1 E4	U58011
18016	Nf2	neurofibromatosis 2	11 A1\|11 0.25 cM	L27090
				AA120153
16453	Jak3	Janus kinase 3	8 B3.3\|8 33.0 cM	Q62137
20190	Ryr1	ryanodine receptor 1, skeletal muscle	7 A2-B3\|7 10.0 cM	U23754
12337	Capn5	calpain 5	7 E2	U85020
5157				D37965
52715	Ccdc43	coiled-coil domain containing 43	11 E1\|11 60.0 cM	W97942
13043	Cttn	cortactin	7 F5	U03184
77106	Tmem181	transmembrane protein 181	17 A1	AA423204
				AA432818
67392	4833420G17Rik	RIKEN cDNA 4833420G17 gene	13 D2.3	W84055
381280	6430706D22Rik	RIKEN cDNA 6430706D22 gene	1 D	AA048171
71472	Usp19	ubiquitin specific peptidase 19	9 F2	AA254871
69908	Rab3b	RAB3B, member RAS oncogene family	4 C7	AA030574
18115	Nnt	nicotinamide nucleotide transhydrogenase	13 D2\|13 64.0 cM	AF037327
218232	Ptpdc1	protein tyrosine phosphatase domain containing 1	13 A5	AA388221
6183				AF058761
				Z93024
67760	Slc38a2	solute carrier family 38, member 2	15 F1	AA245554
76000	5033430I15Rik	RIKEN cDNA 5033430I15 gene	13 A5	AA221680
				AC005324
54371	Chst2	carbohydrate sulfotransferase 2	-	AB011451
27999	D6Wsu176e	DNA segment, Chr 6, Wayne State University 176, expressed	6 A3.1\|6 2.0 cM	AA509602
319839	A530020G20Rik	RIKEN cDNA A530020G20 gene	3 G1	AA543468
60347				X99330
23831	Car14	carbonic anhydrase 14	3 F2.1	AB005450
81761				D87515
3782				AF031815
73074	2900086B20Rik	RIKEN cDNA 2900086B20 gene	-	AA060336
12709	Ckb	creatine kinase, brain	12 F1\|12 55.0 cM	M74149
234407	Glt25d1	glycosyltransferase 25 domain containing 1	8 B3.3	W36470
18597	Pdha1	pyruvate dehydrogenase E1 alpha 1	X F3-F4\|X 66.5 cM	M76727
22709	Zfp51	zinc finger protein 51	17 A3.2\|17 9.9 cM	M74235
19063	Ppt1	palmitoyl-protein thioesterase 1	4 D1-D3\|4 59.1 cM	AF071025
15018	H2-Q7	histocompatibility 2, Q region locus 7	17 B1\|17 19.19 cM	X05389
319944	Taf2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor	15 D1	AA028778
76987	Hdhd2	haloacid dehalogenase-like hydrolase domain containing 2	18 E3	AA268225
15018	H2-Q7	histocompatibility 2, Q region locus 7	17 B1\|17 19.19 cM	X03210
170942	Erdr1	erythroid differentiation regulator 1	-	AJ007909