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Gene Information
Gene ID:218232
Full Name:protein tyrosine phosphatase domain containing 1
Organism:Mus musculus (Mouse)
Genetic Location:13 A5
Physical Location:48673240-48720941 on NC_000079.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 138639    Symbol (Name): PTPDC1 (protein tyrosine phosphatase domain containing 1)
Ortholog Status:The human GeneID 138639 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AA388221
Fold Change:1.7, 1.6
Note:ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR.
Dataset Information
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_207232.1NP_997115.1NC_000079.5 range: 48673240..48720941, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004721phosphoprotein phosphatase activityMolecular FunctionIEA
GO:0004725protein tyrosine phosphatase activityMolecular FunctionIEA
GO:0008138protein tyrosine/serine/threonine phosphatase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0016791phosphoric monoester hydrolase activityMolecular FunctionIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessIEA
GO:0016311dephosphorylationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:218232