ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ptpdc1

Full Name:

protein tyrosine phosphatase domain containing 1

Alias:

AI843923|AW456874

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

13 A5

Physical Location:

48673240-48720941 on NC_000079.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 138639 Symbol (Name): PTPDC1 (protein tyrosine phosphatase domain containing 1)

Ortholog Status:

The human GeneID 138639 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AA388221
Fold Change:		1.7, 1.6
Note:		ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR.

Dataset Information

Name:		11410715
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Ethanol sensitivity
Publication:		Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:		Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_207232.1	NP_997115.1	NC_000079.5 range: 48673240..48720941, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	IEA
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IEA
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA
GO:0016311	dephosphorylation	Biological Process	IEA