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Gene Information
Gene ID:19063
Full Name:palmitoyl-protein thioesterase 1
Organism:Mus musculus (Mouse)
Genetic Location:4 D1-D3|4 59.1 cM
Physical Location:122513484-122536417 on NC_000070.5
Gene Type:protein-coding
Human Ortholog:GeneID: 5538    Symbol (Name): PPT1 (palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile))
Ortholog Status:The human GeneID 5538 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF071025
Fold Change:1.7, 3.0
Note:ISS preferentially expressed gene. Two ratios of ISS/ILS are from cDNA array and RT-PCR.
Dataset Information
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008917.2NP_032943.2NC_000070.5 range: 122513484..122536417
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043025cell somaCellular ComponentIDA (10611498)
GO:0005615extracellular spaceCellular ComponentIDA (9685319)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005764lysosomeCellular ComponentIDA (9685319)
GO:0005764lysosomeCellular ComponentIMP (16242638)
GO:0030424axonCellular ComponentIDA (12483688)
GO:0030425dendriteCellular ComponentIDA (10611498)
GO:0008474palmitoyl-(protein) hydrolase activityMolecular FunctionIMP (11717424|16242638)
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0008474palmitoyl-(protein) hydrolase activityMolecular FunctionIDA (12483688)
GO:0032429regulation of phospholipase A2 activityBiological ProcessIMP (17341491)
GO:0044257cellular protein catabolic processBiological ProcessIMP (16368712)
GO:0002084protein depalmitoylationBiological ProcessIMP (11717424|16242638)
GO:0008344adult locomotory behaviorBiological ProcessIMP (11717424|15649713)
GO:0008306associative learningBiological ProcessIMP (15885820)
GO:0007625grooming behaviorBiological ProcessIMP (11717424)
GO:0007601visual perceptionBiological ProcessIMP (15649713)
GO:0007269neurotransmitter secretionBiological ProcessIMP (16242638)
GO:0007040lysosome organization and biogenesisBiological ProcessIMP (16368712|16542649)
GO:0006907pinocytosisBiological ProcessISO
GO:0006898receptor-mediated endocytosisBiological ProcessISO
GO:0006464protein modification processBiological ProcessIEA
GO:0044265cellular macromolecule catabolic processBiological ProcessIMP (15647513)
Other Database Cross Links
NCBI Entrez Gene:19063