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Gene Information
Gene ID:18115
Full Name:nicotinamide nucleotide transhydrogenase
Organism:Mus musculus (Mouse)
Genetic Location:13 D2|13 64.0 cM
Physical Location:120123123-120197817 on NC_000079.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 23530    Symbol (Name): NNT (nicotinamide nucleotide transhydrogenase)
Ortholog Status:The human GeneID 23530 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF037327
Fold Change:1.7, 1.7
Note:ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR.
Dataset Information
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008710.3NP_032736.2NC_000079.5 range: 120123123..120197817, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0005739mitochondrionCellular ComponentIDA (14651853)
GO:0005743mitochondrial inner membraneCellular ComponentIDA (12865426)
GO:0016020membraneCellular ComponentIEA
GO:0003824catalytic activityMolecular FunctionIEA
GO:0009055electron carrier activityMolecular FunctionIEA
GO:0008750NAD(P)+ transhydrogenase (AB-specific) activityMolecular FunctionIEA
GO:0008746NAD(P) transhydrogenase activityMolecular FunctionIEA
GO:0005488bindingMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0015992proton transportBiological ProcessIEA
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:18115