ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Glt25d1

Full Name:

glycosyltransferase 25 domain containing 1

Alias:

2810024B22Rik|MGC38524

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 B3.3

Physical Location:

74134894-74148809 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 79709 Symbol (Name): GLT25D1 (glycosyltransferase 25 domain containing 1)

Ortholog Status:

The human GeneID 79709 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		W36470
Fold Change:		1.6, 1.6
Note:		ISS preferentially expressed gene. Two ratios of ISS/ILS are from cDNA array and RT-PCR.

Dataset Information

Name:		11410715
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Ethanol sensitivity
Publication:		Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:		Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_146211.3	NP_666323.2	NC_000074.5 range: 74134894..74148809

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function	IEA
GO:0009103	lipopolysaccharide biosynthetic process	Biological Process	IEA