| Gene Information |
| Gene ID: | | 16763 |
| Symbol: | | Lad1 |
| Full Name: | | ladinin |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 1 |
| Genetic Location: | | 1 E4 |
| Physical Location: | | 137715174-137729917 on NC_000067.5 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 3898 Symbol (Name): LAD1 (ladinin 1) |
| Ortholog Status: | | The human GeneID 3898 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | U58011 | | Fold Change: | | 3.9, 2.1 | | Note: | | ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR. |
| | Dataset Information | | Name: | | 11410715 | | Method: | | Microarray | | Tissue: | | Whole brain | | Phenotype: | | Ethanol sensitivity | | Publication: | | Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed | | Summary: | | Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | IEA | |
| GO:0005578 | proteinaceous extracellular matrix | Cellular Component | IEA | |
| GO:0005604 | basement membrane | Cellular Component | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 16763 |
| MGI: | |
| Ensembl: | | ENSMUSG00000041782 |
| dbSNP: | | Lad1 |
| AceView: | | Lad1 |
