ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc38a2

Full Name:

solute carrier family 38, member 2

Alias:

5033402L14Rik|AI316867|ATA2|SAT2|mKIAA1382

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 F1

Physical Location:

96517822-96530128 on NC_000081.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 54407 Symbol (Name): SLC38A2 (solute carrier family 38, member 2)

Ortholog Status:

The human GeneID 54407 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AA245554
Fold Change:		5.8, 3.2
Note:		ISS preferentially expressed gene. Two ratios of ISS/ILS are from cDNA array and RT-PCR.

Dataset Information

Name:		11410715
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Ethanol sensitivity
Publication:		Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:		Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_175121.3	NP_780330.2	NC_000081.5 range: 96517822..96530128, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IDA (17003038)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0015293	symporter activity	Molecular Function	IEA
GO:0015171	amino acid transmembrane transporter activity	Molecular Function	IDA (17003038)
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0006865	amino acid transport	Biological Process	IDA (17003038)
GO:0006814	sodium ion transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA