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Gene Information
Gene ID:77106
Symbol:Tmem181
Full Name:transmembrane protein 181
Alias:5930418K15Rik|C76977|Gpr178|mKIAA1423
Organism:Mus musculus (Mouse)
Chromosome:17
Genetic Location:17 A1
Physical Location:6270474-6305782 on NC_000083.5
Gene Type:protein-coding
Human Ortholog:GeneID: 57583    Symbol (Name): TMEM181 (transmembrane protein 181)
Ortholog Status:The human GeneID 57583 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AA423204
Fold Change:2.5, 3.4
Note:ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR.
Dataset Information
Name:11410715
Method:Microarray
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Information
Original ID1:5930418K15Rik
Original ID2:AW125272
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001033178.2NP_001028350.1NC_000083.5 range: 6270474..6305782
Other Database Cross Links
NCBI Entrez Gene:77106
MGI:
Ensembl:ENSMUSG00000038141
dbSNP:Tmem181
AceView:Tmem181