| Gene Information |
| Gene ID: | | 77106 |
| Symbol: | | Tmem181 |
| Full Name: | | transmembrane protein 181 |
| Alias: | | 5930418K15Rik|C76977|Gpr178|mKIAA1423 |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 17 |
| Genetic Location: | | 17 A1 |
| Physical Location: | | 6270474-6305782 on NC_000083.5 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 57583 Symbol (Name): TMEM181 (transmembrane protein 181) |
| Ortholog Status: | | The human GeneID 57583 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | AA423204 | | Fold Change: | | 2.5, 3.4 | | Note: | | ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR. |
| | Dataset Information | | Name: | | 11410715 | | Method: | | Microarray | | Tissue: | | Whole brain | | Phenotype: | | Ethanol sensitivity | | Publication: | | Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed | | Summary: | | Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice. |
| | Gene Information | | Original ID1: | | 5930418K15Rik | | Original ID2: | | AW125272 |
| | Dataset Information | | Name: | | 15745951 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens, prefrontal cortex, and ventral tegmental area | | Phenotype: | | Acute ethanol response | | Publication: | | Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed | | Summary: | | The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area. |
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| Gene Refseq Sequence Annotation |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 77106 |
| MGI: | |
| Ensembl: | | ENSMUSG00000038141 |
| dbSNP: | | Tmem181 |
| AceView: | | Tmem181 |
