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Gene Information
Gene ID:15018
Full Name:histocompatibility 2, Q region locus 7
Organism:Mus musculus (Mouse)
Genetic Location:17 B1|17 19.19 cM
Physical Location:35576160-35580587 on NC_000083.5
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X05389
Fold Change:1.7, 1.6
Note:ISS preferentially expressed gene. Two ratios of ISS/ILS are from cDNA array and RT-PCR.
Gene Information
Original ID1:X03210
Fold Change:2.1, 1.6
Note:ISS preferentially expressed gene. Two ratios of ISS/ILS are from cDNA array and RT-PCR.
Dataset Information
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010394.3NP_034524.2NC_000083.5 range: 35576160..35580587
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0042612MHC class I protein complexCellular ComponentIEA
GO:0002474antigen processing and presentation of peptide antigen via MHC class IBiological ProcessIEA
GO:0006955immune responseBiological ProcessIEA
GO:0019882antigen processing and presentationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:15018