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Gene Information
Gene ID:18016
Full Name:neurofibromatosis 2
Organism:Mus musculus (Mouse)
Genetic Location:11 A1|11 0.25 cM
Physical Location:4665850-4749529 on NC_000077.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4771    Symbol (Name): NF2 (neurofibromin 2 (merlin))
Ortholog Status:The human GeneID 4771 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L27090
Fold Change:4.5, 3.6
Note:ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR.
Dataset Information
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010898.3NP_035028.2NC_000077.5 range: 4665850..4749529, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030175filopodiumCellular ComponentIDA (9563848)
GO:0032154cleavage furrowCellular ComponentIDA (9631655)
GO:0019898extrinsic to membraneCellular ComponentIEA
GO:0030027lamellipodiumCellular ComponentIDA (9563848)
GO:0005912adherens junctionCellular ComponentIMP (12695331)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIDA (8547603|15133494)
GO:0005634nucleusCellular ComponentIDA (15133494)
GO:0001726ruffleCellular ComponentIDA (9563848)
GO:0005515protein bindingMolecular FunctionIPI (12695331|14580336|16405865)
GO:0005488bindingMolecular FunctionIEA
GO:0005198structural molecule activityMolecular FunctionIEA
GO:0008092cytoskeletal protein bindingMolecular FunctionIEA
GO:0042127regulation of cell proliferationBiological ProcessIMP (12695331)
GO:0042475odontogenesis of dentine-containing teethBiological ProcessIMP (10887156)
GO:0043409negative regulation of MAPKKK cascadeBiological ProcessIMP (16405865)
GO:0045216cell-cell junction assembly and maintenanceBiological ProcessIMP (12695331)
GO:0001707mesoderm formationBiological ProcessIMP (9171370)
GO:0008285negative regulation of cell proliferationBiological ProcessIMP (9553042|10887156)
GO:0007398ectoderm developmentBiological ProcessIMP (9171370)
GO:0007049cell cycleBiological ProcessIEA
GO:0006469negative regulation of protein kinase activityBiological ProcessIMP (16405865)
GO:0006469negative regulation of protein kinase activityBiological ProcessIDA (14580336)
GO:0045786negative regulation of cell cycleBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:18016