ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdha1

Full Name:

pyruvate dehydrogenase E1 alpha 1

Alias:

Pdha-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

X F3-F4|X 66.5 cM

Physical Location:

156560150-156576267 on NC_000086.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5160 Symbol (Name): PDHA1 (pyruvate dehydrogenase (lipoamide) alpha 1)

Ortholog Status:

The human GeneID 5160 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M76727
Fold Change:		1.6, 1.7
Note:		ISS preferentially expressed gene. Two ratios of ISS/ILS are from cDNA array and RT-PCR.

Dataset Information

Name:		11410715
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Ethanol sensitivity
Publication:		Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:		Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008810.2	NP_032836.1	NC_000086.6 range: 156560150..156576267, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0004738	pyruvate dehydrogenase activity	Molecular Function	IMP (11708858)
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	Molecular Function	IEA
GO:0006096	glycolysis	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA