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Gene Information
Gene ID:18597
Full Name:pyruvate dehydrogenase E1 alpha 1
Organism:Mus musculus (Mouse)
Genetic Location:X F3-F4|X 66.5 cM
Physical Location:156560150-156576267 on NC_000086.6, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5160    Symbol (Name): PDHA1 (pyruvate dehydrogenase (lipoamide) alpha 1)
Ortholog Status:The human GeneID 5160 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M76727
Fold Change:1.6, 1.7
Note:ISS preferentially expressed gene. Two ratios of ISS/ILS are from cDNA array and RT-PCR.
Dataset Information
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008810.2NP_032836.1NC_000086.6 range: 156560150..156576267, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005739mitochondrionCellular ComponentIDA (14651853)
GO:0004738pyruvate dehydrogenase activityMolecular FunctionIMP (11708858)
GO:0004739pyruvate dehydrogenase (acetyl-transferring) activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0016624oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptorMolecular FunctionIEA
GO:0006096glycolysisBiological ProcessIEA
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:18597