ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Usp19

Full Name:

ubiquitin specific peptidase 19

Alias:

8430421I07Rik|AI047774|Zmynd9

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 F2

Physical Location:

108393078-108404029 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10869 Symbol (Name): USP19 (ubiquitin specific peptidase 19)

Ortholog Status:

The human GeneID 10869 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AA254871
Fold Change:		1.8, 1.8
Note:		ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR.

Dataset Information

Name:		11410715
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Ethanol sensitivity
Publication:		Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:		Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_027804.2	NP_082080.2	NC_000075.5 range: 108393078..108404029

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004197	cysteine-type endopeptidase activity	Molecular Function	RCA (16141072)
GO:0004221	ubiquitin thiolesterase activity	Molecular Function	RCA (16141072)
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	RCA (16141072)
GO:0006512	ubiquitin cycle	Biological Process	IEA