Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:20190
Full Name:ryanodine receptor 1, skeletal muscle
Organism:Mus musculus (Mouse)
Genetic Location:7 A2-B3|7 10.0 cM
Physical Location:29788358-29910169 on NC_000073.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6261    Symbol (Name): RYR1 (ryanodine receptor 1 (skeletal))
Ortholog Status:The human GeneID 6261 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U23754
Fold Change:9.7, 2.5
Note:ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR.
Dataset Information
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009109.2NP_033135.2NC_000073.5 range: 29788358..29910169, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030315T-tubuleCellular ComponentIDA (8943043|15536090)
GO:0030314junctional membrane complexCellular ComponentIDA (10444070)
GO:0016529sarcoplasmic reticulumCellular ComponentIDA (7832748|8943043|11784029|12954602|15536090)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentRCA (12466851)
GO:0005624membrane fractionCellular ComponentIDA (7832748)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (15102471)
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005245voltage-gated calcium channel activityMolecular FunctionIDA (12954602)
GO:0005261cation channel activityMolecular FunctionRCA (12466851)
GO:0006811ion transportBiological ProcessRCA (12466851)
GO:0006937regulation of muscle contractionBiological ProcessTAS (11784029)
GO:0006936muscle contractionBiological ProcessIDA (12954602)
GO:0006816calcium ion transportBiological ProcessIDA (12954602)
GO:0006810transportBiological ProcessIEA
GO:0006812cation transportBiological ProcessRCA (12466851)
Other Database Cross Links
NCBI Entrez Gene:20190