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Gene Information
Gene ID:381280
Symbol:6430706D22Rik
Full Name:RIKEN cDNA 6430706D22 gene
Alias:Gm975|MGC66590|mfleg1
Organism:Mus musculus (Mouse)
Chromosome:1
Genetic Location:1 D
Physical Location:90159683-90174094 on NC_000067.5, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AA048171
Fold Change:1.8, 2.4
Note:ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR.
Dataset Information
Name:11410715
Method:Microarray
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_198652.1NP_941054.1NC_000067.5 range: 90159683..90174094, complement
Other Database Cross Links
NCBI Entrez Gene:381280
MGI:
Ensembl:ENSMUSG00000044783
dbSNP:6430706D22Rik
AceView:6430706D22Rik