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Gene Information
Gene ID:54371
Symbol:Chst2
Full Name:carbohydrate sulfotransferase 2
Alias:AI428561|AW121776|C130041E03Rik|Chts2|GST-2|GlcNAc6ST|Gn6st
Organism:Mus musculus (Mouse)
Chromosome:9
Physical Location:95304919-95307140 on NC_000075.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9435    Symbol (Name): CHST2 (carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2)
Ortholog Status:The human GeneID 9435 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AB011451
Fold Change:3.1, 2.1
Note:ISS preferentially expressed gene. Two ratios of ISS/ILS are from cDNA array and RT-PCR.
Dataset Information
Name:11410715
Method:Microarray
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Information
Original ID1:Chst2
Original ID2:AW121776
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_018763.2NP_061233.2NC_000075.5 range: 95304919..95307140, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0008146sulfotransferase activityMolecular FunctionIDA (9712885)
GO:0016740transferase activityMolecular FunctionIEA
GO:0005975carbohydrate metabolic processBiological ProcessIEA
GO:0006044N-acetylglucosamine metabolic processBiological ProcessTAS (9712885)
GO:0006954inflammatory responseBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:54371
MGI:
Ensembl:ENSMUSG00000033350
dbSNP:Chst2
AceView:Chst2