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Gene Information
Gene ID:16453
Full Name:Janus kinase 3
Organism:Mus musculus (Mouse)
Genetic Location:8 B3.3|8 33.0 cM
Physical Location:74200472-74214472 on NC_000074.5
Gene Type:protein-coding
Human Ortholog:GeneID: 3718    Symbol (Name): JAK3 (Janus kinase 3 (a protein tyrosine kinase, leukocyte))
Ortholog Status:The human GeneID 3718 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Q62137
Fold Change:4.0, 2.2
Note:ILS preferentially expressed gene. Two ratios of ILS/ISS are from cDNA array and RT-PCR.
Dataset Information
Tissue:Whole brain
Phenotype:Ethanol sensitivity
Publication:Xu et al. Alcohol Clin Exp Res. (2001) Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. PubMed
Summary:Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RTPCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice.
Gene Information
Original ID1:Jak3
Original ID2:AI854103
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Caws3/Alcw6Chronic Alcohol Withdrawal8 16-43 (cM)3.50.0003SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010589.5NP_034719.2NC_000074.5 range: 74200472..74214472
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (10872802)
GO:0004718Janus kinase activityMolecular FunctionIDA (8022486)
GO:0004715non-membrane spanning protein tyrosine kinase activityMolecular FunctionIEA
GO:0004713protein-tyrosine kinase activityMolecular FunctionIDA (10872802)
GO:0004672protein kinase activityMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIMP (10485657)
GO:0019221cytokine and chemokine mediated signaling pathwayBiological ProcessIDA (8022486)
GO:0018108peptidyl-tyrosine phosphorylationBiological ProcessIDA (10872802)
GO:0007243protein kinase cascadeBiological ProcessIDA (8022486)
GO:0007167enzyme linked receptor protein signaling pathwayBiological ProcessIDA (8022486)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0048535lymph node developmentBiological ProcessTAS (10687308)
Other Database Cross Links
NCBI Entrez Gene:16453