ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cxcr4

Full Name:

chemokine (C-X-C motif) receptor 4

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 E4|1 67.4 cM

Physical Location:

130484775-130488875 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7852 Symbol (Name): CXCR4 (chemokine (C-X-C motif) receptor 4)

Ortholog Status:

The human GeneID 7852 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009911.3	NP_034041.2	NC_000067.5 range: 130484775..130488875, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030426	growth cone	Cellular Component	IDA (16129397)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0016493	C-C chemokine receptor activity	Molecular Function	IEA
GO:0016494	C-X-C chemokine receptor activity	Molecular Function	IEA
GO:0030334	regulation of cell migration	Biological Process	IGI (16166380)
GO:0001569	patterning of blood vessels	Biological Process	IMP (15626744)
GO:0030334	regulation of cell migration	Biological Process	IMP (12183377\|12900445)
GO:0009887	organ morphogenesis	Biological Process	TAS (9634237)
GO:0008354	germ cell migration	Biological Process	IMP (12900445)
GO:0008045	motor axon guidance	Biological Process	IMP (16129397)
GO:0007420	brain development	Biological Process	IMP (12183377)
GO:0007399	nervous system development	Biological Process	TAS (9634238)
GO:0007281	germ cell development	Biological Process	IMP (12900445)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0001764	neuron migration	Biological Process	IDA (12900445)
GO:0001667	ameboidal cell migration	Biological Process	IMP (15626744)
GO:0042098	T cell proliferation	Biological Process	IMP (12707343)