ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CXCR4

Full Name:

chemokine (C-X-C motif) receptor 4

Alias:

CD184|D2S201E|FB22|HM89|HSY3RR|LAP3|LCR1|LESTR|NPY3R|NPYR|NPYRL|NPYY3R|WHIM

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q21

Physical Location:

136588388-136592194 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12767 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CXCR4

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (10644702)
GO:0031252	leading edge	Cellular Component	IDA (12421915)
GO:0005737	cytoplasm	Cellular Component	TAS (10415069)
GO:0005886	plasma membrane	Cellular Component	TAS (10393923\|10644702)
GO:0015026	coreceptor activity	Molecular Function	TAS (10754293)
GO:0016493	C-C chemokine receptor activity	Molecular Function	IEA
GO:0016494	C-X-C chemokine receptor activity	Molecular Function	NAS (9468539)
GO:0032027	myosin light chain binding	Molecular Function	IDA (12421915)
GO:0005515	protein binding	Molecular Function	IPI (12421915)
GO:0003779	actin binding	Molecular Function	IDA (12421915)
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0019059	initiation of viral infection	Biological Process	EXP (12091904)
GO:0009615	response to virus	Biological Process	TAS (10583963)
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	TAS (10228019)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (10644702)
GO:0007165	signal transduction	Biological Process	IEA
GO:0006955	immune response	Biological Process	TAS (10802710)
GO:0006954	inflammatory response	Biological Process	TAS (8276799)
GO:0006935	chemotaxis	Biological Process	TAS (10802710)
GO:0006915	apoptosis	Biological Process	TAS (10942389)
GO:0001666	response to hypoxia	Biological Process	IEP (15174142)
GO:0000187	activation of MAPK activity	Biological Process	TAS (10570282)