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Gene Information
Gene ID:12785
Full Name:cellular nucleic acid binding protein
Organism:Mus musculus (Mouse)
Genetic Location:6 D1-D2
Physical Location:87793072-87800988 on NC_000072.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7555    Symbol (Name): CNBP (CCHC-type zinc finger, nucleic acid binding protein)
Ortholog Status:The human GeneID 7555 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cnbp1
Original ID2:X63866
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013493.3NP_038521.1NC_000072.5 range: 87793072..87800988, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentIDA (7896269)
GO:0005634nucleusCellular ComponentIDA (12706888)
GO:0005634nucleusCellular ComponentIDA (7896269)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIDA (7896269)
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0003676nucleic acid bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionRCA (12466851)
GO:0003677DNA bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006695cholesterol biosynthetic processBiological ProcessRCA (12466851)
GO:0008284positive regulation of cell proliferationBiological ProcessIDA (12706888)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (12706888)
Other Database Cross Links
NCBI Entrez Gene:12785