ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cnbp

Full Name:

cellular nucleic acid binding protein

Alias:

AA408710|Cnbp1|Znf9

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 D1-D2

Physical Location:

87793072-87800988 on NC_000072.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7555 Symbol (Name): CNBP (CCHC-type zinc finger, nucleic acid binding protein)

Ortholog Status:

The human GeneID 7555 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cnbp1
Original ID2:		X63866

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013493.3	NP_038521.1	NC_000072.5 range: 87793072..87800988, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	IDA (7896269)
GO:0005634	nucleus	Cellular Component	IDA (12706888)
GO:0005634	nucleus	Cellular Component	IDA (7896269)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IDA (7896269)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	RCA (12466851)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006695	cholesterol biosynthetic process	Biological Process	RCA (12466851)
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA (12706888)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (12706888)