ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cntfr

Full Name:

ciliary neurotrophic factor receptor

Alias:

Cntfralpha

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 A5|4 19.9 cM

Physical Location:

41604528-41644073 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1271 Symbol (Name): CNTFR (ciliary neurotrophic factor receptor)

Ortholog Status:

The human GeneID 1271 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF068615
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016673.1	NP_057882.1	NC_000070.5 range: 41604528..41644073, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	RCA (12466851)
GO:0031225	anchored to membrane	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004896	hematopoietin/interferon-class (D200-domain) cytokine receptor activity	Molecular Function	RCA (12466851)
GO:0005515	protein binding	Molecular Function	IPI (15051883)
GO:0008284	positive regulation of cell proliferation	Biological Process	IGI (15051883)