ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Col1a2

Full Name:

collagen, type I, alpha 2

Alias:

AA960264|AI325291|Col1a-2|Cola-2|Cola2|oim

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 A1|6 0.68 cM

Physical Location:

4455696-4491542 on NC_000072.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1278 Symbol (Name): COL1A2 (collagen, type I, alpha 2)

Ortholog Status:

The human GeneID 1278 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Col1a2
Original ID2:		AW123632

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007743.2	NP_031769.2	NC_000072.5 range: 4455696..4491542

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0005581	collagen	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0005201	extracellular matrix structural constituent	Molecular Function	IEA
GO:0006817	phosphate transport	Biological Process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	NAS (15609325)