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Gene Information
Gene ID:12843
Full Name:collagen, type I, alpha 2
Organism:Mus musculus (Mouse)
Genetic Location:6 A1|6 0.68 cM
Physical Location:4455696-4491542 on NC_000072.5
Gene Type:protein-coding
Human Ortholog:GeneID: 1278    Symbol (Name): COL1A2 (collagen, type I, alpha 2)
Ortholog Status:The human GeneID 1278 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Col1a2
Original ID2:AW123632
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007743.2NP_031769.2NC_000072.5 range: 4455696..4491542
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005578proteinaceous extracellular matrixCellular ComponentIEA
GO:0005581collagenCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005198structural molecule activityMolecular FunctionIEA
GO:0005201extracellular matrix structural constituentMolecular FunctionIEA
GO:0006817phosphate transportBiological ProcessIEA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessNAS (15609325)
Other Database Cross Links
NCBI Entrez Gene:12843