ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cplx2

Full Name:

complexin 2

Alias:

921-L|AI413745|AW492120

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

13 B1

Physical Location:

54472712-54485277 on NC_000079.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10814 Symbol (Name): CPLX2 (complexin 2)

Ortholog Status:

The human GeneID 10814 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D38613
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009946.2	NP_034076.1	NC_000079.5 range: 54472712..54485277

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0019905	syntaxin binding	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006836	neurotransmitter transport	Biological Process	RCA (12466851)
GO:0006887	exocytosis	Biological Process	IEA
GO:0006904	vesicle docking during exocytosis	Biological Process	RCA (12466851)
GO:0006944	membrane fusion	Biological Process	RCA (12466851)
GO:0007033	vacuole organization and biogenesis	Biological Process	RCA (12466851)
GO:0043303	mast cell degranulation	Biological Process	IEA