ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cpt2

Full Name:

carnitine palmitoyltransferase 2

Alias:

AI323697|CPTII

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 C7|4 54.4 cM

Physical Location:

107576586-107596138 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1376 Symbol (Name): CPT2 (carnitine palmitoyltransferase II)

Ortholog Status:

The human GeneID 1376 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cpt2
Original ID2:		AV266650

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009949.2	NP_034079.2	NC_000070.5 range: 107576586..107596138, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0016020	membrane	Cellular Component	IEA
GO:0004095	carnitine O-palmitoyltransferase activity	Molecular Function	IEA
GO:0008415	acyltransferase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0006631	fatty acid metabolic process	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA