ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cyb561

Full Name:

cytochrome b-561

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 E1|11 65.0 cM

Physical Location:

105795017-105805460 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1534 Symbol (Name): CYB561 (cytochrome b-561)

Ortholog Status:

The human GeneID 1534 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cyb561
Original ID2:		U16297

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007805.4	NP_031831.2	NC_000077.5 range: 105795017..105805460, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0000293	ferric-chelate reductase activity	Molecular Function	IDA (14499595)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA