ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cyp11b2

Full Name:

cytochrome P450, family 11, subfamily b, polypeptide 2

Alias:

Cpn2|Cyp11b|Cyp11b-2|MGC151285

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 D3|15 44.9 cM

Physical Location:

74681468-74686654 on NC_000081.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1585 Symbol (Name): CYP11B2 (cytochrome P450, family 11, subfamily B, polypeptide 2)

Ortholog Status:

The human GeneID 1585 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC
Aaq1/Etacc	Alcohol Acceptance	15	30	15-48 (cM)	3.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009991.3	NP_034121.2	NC_000081.5 range: 74681468..74686654, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0004497	monooxygenase activity	Molecular Function	IEA
GO:0004507	steroid 11-beta-monooxygenase activity	Molecular Function	IDA (1686470\|8645611)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0047783	corticosterone 18-monooxygenase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0042756	drinking behavior	Biological Process	IMP (16118390)
GO:0032342	aldosterone biosynthetic process	Biological Process	IDA (1686470\|8645611)
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	Biological Process	IMP (16118390)
GO:0006700	C21-steroid hormone biosynthetic process	Biological Process	IEA
GO:0002017	regulation of blood volume by renal aldosterone	Biological Process	IMP (16118390)
GO:0050801	ion homeostasis	Biological Process	IMP (16118390)