ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CYP11B2

Full Name:

cytochrome P450, family 11, subfamily B, polypeptide 2

Alias:

ALDOS|CPN2|CYP11B|CYP11BL|P-450C18|P450C18|P450aldo

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8q21-q22

Physical Location:

143988976-143996260 on NC_000008.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 13072 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CYP11B2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000498.3	NP_000489.3	NC_000008.9 range: 143988976..143996260, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0004497	monooxygenase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0019825	oxygen binding	Molecular Function	NR
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0047783	corticosterone 18-monooxygenase activity	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0004507	steroid 11-beta-monooxygenase activity	Molecular Function	TAS (1741400)
GO:0006704	glucocorticoid biosynthetic process	Biological Process	TAS (1741400)
GO:0006700	C21-steroid hormone biosynthetic process	Biological Process	IEA
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0008217	regulation of blood pressure	Biological Process	TAS (1518866)