ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dapk3

Full Name:

death-associated kinase 3

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 C1|10 43.0 cM

Physical Location:

80646749-80655742 on NC_000076.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1613 Symbol (Name): DAPK3 (death-associated protein kinase 3)

Ortholog Status:

The human GeneID 1613 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Dapk3
Original ID2:		AB007143

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007828.1	NP_031854.1	NC_000076.5 range: 80646749..80655742

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEP (9488481)
GO:0005634	nucleus	Cellular Component	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (9488481)
GO:0004672	protein kinase activity	Molecular Function	RCA (12466851)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (9488481)
GO:0005515	protein binding	Molecular Function	IPI (12917339)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (9488481)
GO:0006915	apoptosis	Biological Process	IEA
GO:0007243	protein kinase cascade	Biological Process	IDA (9488481)
GO:0016568	chromatin modification	Biological Process	IEA
GO:0006917	induction of apoptosis	Biological Process	IMP (9488481)