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Gene Information
Gene ID:13197
Full Name:growth arrest and DNA-damage-inducible 45 alpha
Organism:Mus musculus (Mouse)
Genetic Location:6 C1
Physical Location:66985089-66987400 on NC_000072.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1647    Symbol (Name): GADD45A (growth arrest and DNA-damage-inducible, alpha)
Ortholog Status:The human GeneID 1647 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gadd45a
Original ID2:U00937
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007836.1NP_031862.1NC_000072.5 range: 66985089..66987400, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentTAS (12124778)
GO:0005515protein bindingMolecular FunctionIPI (12124778)
GO:0006469negative regulation of protein kinase activityBiological ProcessIDA (12124778)
GO:0006974response to DNA damage stimulusBiological ProcessIEA
GO:0007049cell cycleBiological ProcessIEA
GO:0007050cell cycle arrestBiological ProcessIEA
GO:0007098centrosome cycleBiological ProcessIGI (15123655)
GO:0051726regulation of cell cycleBiological ProcessIDA (12124778)
Other Database Cross Links
NCBI Entrez Gene:13197