ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gadd45a

Full Name:

growth arrest and DNA-damage-inducible 45 alpha

Alias:

AA545191|Ddit1|GADD45

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 C1

Physical Location:

66985089-66987400 on NC_000072.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1647 Symbol (Name): GADD45A (growth arrest and DNA-damage-inducible, alpha)

Ortholog Status:

The human GeneID 1647 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gadd45a
Original ID2:		U00937

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007836.1	NP_031862.1	NC_000072.5 range: 66985089..66987400, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (12124778)
GO:0005515	protein binding	Molecular Function	IPI (12124778)
GO:0006469	negative regulation of protein kinase activity	Biological Process	IDA (12124778)
GO:0006974	response to DNA damage stimulus	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0007050	cell cycle arrest	Biological Process	IEA
GO:0007098	centrosome cycle	Biological Process	IGI (15123655)
GO:0051726	regulation of cell cycle	Biological Process	IDA (12124778)