ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

COX6C

Full Name:

cytochrome c oxidase subunit VIc

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8q22-q23

Physical Location:

100959547-100975070 on NC_000008.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12864 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X13238
Fold Change:		1.4, 1.5
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004374.2	NP_004365.1	NC_000008.9 range: 100959547..100975070, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005743	mitochondrial inner membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0004129	cytochrome-c oxidase activity	Molecular Function	IEA
GO:0006091	generation of precursor metabolites and energy	Biological Process	TAS (2849755)