ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cox6c

Full Name:

cytochrome c oxidase, subunit VIc

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 B3.3

Physical Location:

35861730-35868000 on NC_000081.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1345 Symbol (Name): COX6C (cytochrome c oxidase subunit VIc)

Ortholog Status:

The human GeneID 1345 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cox6c
Original ID2:		AW060422

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053071.2	NP_444301.1	NC_000081.5 range: 35861730..35868000, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0019866	organelle inner membrane	Cellular Component	RCA (12466851)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005751	mitochondrial respiratory chain complex IV	Cellular Component	RCA (12466851)
GO:0005743	mitochondrial inner membrane	Cellular Component	IDA (12865426)
GO:0005739	mitochondrion	Cellular Component	RCA (12466851)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0004129	cytochrome-c oxidase activity	Molecular Function	RCA (12466851)
GO:0016491	oxidoreductase activity	Molecular Function	RCA (12466851)
GO:0003674	molecular_function	Molecular Function	ND
GO:0008150	biological_process	Biological Process	ND