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Gene Information
Gene ID:12864
Full Name:cytochrome c oxidase, subunit VIc
Organism:Mus musculus (Mouse)
Genetic Location:15 B3.3
Physical Location:35861730-35868000 on NC_000081.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1345    Symbol (Name): COX6C (cytochrome c oxidase subunit VIc)
Ortholog Status:The human GeneID 1345 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cox6c
Original ID2:AW060422
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053071.2NP_444301.1NC_000081.5 range: 35861730..35868000, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0019866organelle inner membraneCellular ComponentRCA (12466851)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0016020membraneCellular ComponentIEA
GO:0005751mitochondrial respiratory chain complex IVCellular ComponentRCA (12466851)
GO:0005743mitochondrial inner membraneCellular ComponentIDA (12865426)
GO:0005739mitochondrionCellular ComponentRCA (12466851)
GO:0005739mitochondrionCellular ComponentIDA (14651853)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0004129cytochrome-c oxidase activityMolecular FunctionRCA (12466851)
GO:0016491oxidoreductase activityMolecular FunctionRCA (12466851)
GO:0003674molecular_functionMolecular FunctionND
GO:0008150biological_processBiological ProcessND
Other Database Cross Links
NCBI Entrez Gene:12864