ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Egr1

Full Name:

early growth response 1

Alias:

A530045N19Rik|ETR103|Egr-1|Krox-1|Krox-24|Krox24|NGF1-A|NGFI-A|NGFIA|TIS8|Zenk|Zfp-6|Zif268|egr

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 C/D|18 16.0 cM

Physical Location:

35020860-35024609 on NC_000084.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1958 Symbol (Name): EGR1 (early growth response 1)

Ortholog Status:

The human GeneID 1958 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Egr1
Original ID2:		M28845

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007913.5	NP_031939.1	NC_000084.5 range: 35020860..35024609

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISO
GO:0005634	nucleus	Cellular Component	IMP (12165491)
GO:0005622	intracellular	Cellular Component	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IMP (12165491)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IMP (12165491)
GO:0030217	T cell differentiation	Biological Process	IMP (12165491)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (16033766)