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Gene Information
Gene ID:13653
Full Name:early growth response 1
Organism:Mus musculus (Mouse)
Genetic Location:18 C/D|18 16.0 cM
Physical Location:35020860-35024609 on NC_000084.5
Gene Type:protein-coding
Human Ortholog:GeneID: 1958    Symbol (Name): EGR1 (early growth response 1)
Ortholog Status:The human GeneID 1958 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Egr1
Original ID2:M28845
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007913.5NP_031939.1NC_000084.5 range: 35020860..35024609
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISO
GO:0005634nucleusCellular ComponentIMP (12165491)
GO:0005622intracellularCellular ComponentIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIMP (12165491)
GO:0003677DNA bindingMolecular FunctionIEA
GO:0003676nucleic acid bindingMolecular FunctionIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIMP (12165491)
GO:0030217T cell differentiationBiological ProcessIMP (12165491)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (16033766)
Other Database Cross Links
NCBI Entrez Gene:13653