ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Eif1a

Full Name:

eukaryotic translation initiation factor 1A

Alias:

C76390|Ef1a|Eftu|Eif4c|eIF-1A

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 C

Physical Location:

46757357-46769861 on NC_000084.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1964 Symbol (Name): EIF1AX (eukaryotic translation initiation factor 1A, X-linked)

Ortholog Status:

The human GeneID 1964 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Eif1a
Original ID2:		AF026481

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010120.5	NP_034250.3	NC_000084.5 range: 46757357..46769861

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	RCA (16141072)
GO:0003676	nucleic acid binding	Molecular Function	RCA (16141072)
GO:0003723	RNA binding	Molecular Function	RCA (16141072)
GO:0003743	translation initiation factor activity	Molecular Function	RCA (16141072)
GO:0005215	transporter activity	Molecular Function	RCA (16141072)
GO:0006412	translation	Biological Process	IEA
GO:0006413	translational initiation	Biological Process	RCA (16141072)
GO:0006810	transport	Biological Process	RCA (16141072)