ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Erbb3

Full Name:

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Alias:

C76256|Erbb-3|Erbb3r|Her3|MGC117742

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 D3|10 70.0 cM

Physical Location:

128006423-128026556 on NC_000076.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2065 Symbol (Name): ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian))

Ortholog Status:

The human GeneID 2065 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI006228
Fold Change:		-2.1, -1.7, -1.9, -1
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010153.1	NP_034283.1	NC_000076.5 range: 128006423..128026556, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016324	apical plasma membrane	Cellular Component	IDA (15306553)
GO:0016328	lateral plasma membrane	Cellular Component	IDA (15306553)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11276227)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	ISO
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0021545	cranial nerve development	Biological Process	IMP (9338783)
GO:0014037	Schwann cell differentiation	Biological Process	IMP (9338783)
GO:0007507	heart development	Biological Process	IMP (9362461)
GO:0007422	peripheral nervous system development	Biological Process	IMP (9362461)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	ISO
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0043524	negative regulation of neuron apoptosis	Biological Process	IMP (9338783)