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Gene Information
Gene ID:2065
Symbol:ERBB3
Full Name:v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Alias:ErbB-3|HER3|LCCS2|MDA-BF-1|MGC88033|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3
Organism:Homo sapiens (Human)
Chromosome:12
Genetic Location:12q13
Physical Location:54760158-54783394 on NC_000012.10
Gene Type:protein-coding
Orthologs:This gene has Mouse: 13867 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:ERBB3
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001005915.1NP_001005915.1NC_000012.10 range: 54760158..54783394
NM_001982.2NP_001973.2NC_000012.10 range: 54760158..54783394
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043235receptor complexCellular ComponentISS (7514177)
GO:0005887integral to plasma membraneCellular ComponentTAS (2687875)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIDA (11389077)
GO:0005576extracellular regionCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0016323basolateral plasma membraneCellular ComponentIDA (12646923)
GO:0016740transferase activityMolecular FunctionIEA
GO:0019838growth factor bindingMolecular FunctionIPI (11389077)
GO:0030296protein tyrosine kinase activator activityMolecular FunctionIDA (7556068)
GO:0042803protein homodimerization activityMolecular FunctionNAS (11389077)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0046982protein heterodimerization activityMolecular FunctionIDA (10572067)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0004888transmembrane receptor activityMolecular FunctionISS (7514177)
GO:0004714transmembrane receptor protein tyrosine kinase activityMolecular FunctionIEA
GO:0004713protein-tyrosine kinase activityMolecular FunctionIGI (7556068)
GO:0019838growth factor bindingMolecular FunctionISS (7514177)
GO:0042127regulation of cell proliferationBiological ProcessIDA (11389077)
GO:0042060wound healingBiological ProcessNAS (12646923)
GO:0014068positive regulation of phosphoinositide 3-kinase cascadeBiological ProcessTAS (17701904)
GO:0009968negative regulation of signal transductionBiological ProcessIDA (11389077)
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessIGI (7556068)
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessIEA
GO:0007162negative regulation of cell adhesionBiological ProcessIDA (7556068)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0051048negative regulation of secretionBiological ProcessIDA (10559227)
Other Database Cross Links
NCBI Entrez Gene:2065
HGNC:3431
Ensembl:ENSG00000065361
MIM:190151
HPRD:01820
HuGE Navigator:2065
dbSNP:ERBB3
GeneCard:ERBB3
AceView:ERBB3