ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Atp5i

Full Name:

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e

Alias:

Atp5k

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14p22

Physical Location:

1867343-1868471 on NC_005113.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 521 Symbol (Name): ATP5I (ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E)

Ortholog Status:

The human GeneID 521 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Atp5i
Fold Change:		-1.19
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_080481.1	NP_536729.1	NC_005113.2 range: 1867343..1868471

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (1463732)
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	Cellular Component	IEA
GO:0016469	proton-transporting two-sector ATPase complex	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005743	mitochondrial inner membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	Molecular Function	IEA
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	Molecular Function	IEA
GO:0015986	ATP synthesis coupled proton transport	Biological Process	IEA
GO:0015992	proton transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA